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JR-AB2-011

CAS No. : 2411853-34-2

MCE 国际站：JR-AB2-011

产品活性：JR-AB2-011 是一种选择性 mTORC2 抑制剂，IC₅₀ 值为 0.36 μM。JR-AB2-011 通过阻断 Rictor-mTOR 联合体 (K_i: 0.19 μM) 抑制 mTORC2 活性。JR-AB2-011 具有抗多形性胶质母细胞瘤 (GBM) 的活性。

研究领域：PI3K/Akt/mTOR

作用靶点：mTOR

In Vitro: JR-AB2-011 (1 μM; 24 hours) has good anti-GBM properties, blocks mTORC2 signaling and Rictor association with mTOR.
JR-AB2-011 (0.5-2 μM; 48 hours) displays the least toxicity to normal neurons with no significant cytotoxic effects for concentrations up to 10 mM compared to CID613034.

In Vivo: Mice receiving JR-AB2-011 (4 mg/kg; daily i.p. for 10 days; 20 mg/kg; daily i.p. for 10 days) at either dosing regimen display marked inhibition of tumor growth rate (JR-AB2-011 at 4 mg/kg/d; 74% inhibition at end of dosing period; tumor growth delay 10.0 days; JR-AB2-011 at 20 mg/kg/d; 80% inhibition at end of dosing period; tumor growth delay 12.0 days) as compared to mice receiving vehicle alone.

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