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Pentostatin

CAS No. : 53910-25-1

MCE 国际站：Pentostatin

产品活性：Pentostatin (CI-825; Deoxycoformycin) 是一种高效，不可逆的腺苷脱氨酶抑制剂，K_i 值为 2.5 pM。

研究领域：Metabolic Enzyme/Protease  |  Anti-infection

作用靶点：Adenosine Deaminase  |  Antibiotic

In Vivo: In ECP and Pentostatin (CI-825; Deoxycoformycin; 4 mg/m², i.v.) treatment, all dogs develop granulocytopenia with <500 granulocytes/μL from day 4. Thrombocytopenia (<20,000 platelets/μL) occurs from day 7 after HCT with nadirs of 3000 to 14000 platelets/μL. Pentostatin (2 mg/kg) in combination with cordycepin (2 mg/kg) is 100% effective in the T. evansi-infected mice. There is an increase in levels of some biochemical parameters, especially on liver enzymes, which are accompanied by histological lesions in the liver and kidneys. Pentostatin individually has no curative effect on infected groups.

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