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SRT 1720

CAS No. : 925434-55-5

MCE 国际站：SRT 1720

产品活性：SRT 1720 是人 SIRT1 的有效激活剂，EC_1.5 值为 0.16 μM，对 SIRT2 和 SIRT3 的作用较弱，EC_1.5 值分别为 37 μM 和 > 300 μM。

研究领域：Cell Cycle/DNA Damage  |  Epigenetics  |  Autophagy

作用靶点：Sirtuin  |  Autophagy

In Vitro: SRT 1720 effectively decreases the acetylation of p53 in cells even in the absence of SIRT1, and this is attributed to inhibition of histone acetyltransferase p300.

In Vivo: SRT 1720 (10, 30, 100 mg/kg, p.o.) significantly reduces the hyperinsulinaemia after 4 weeks, partially normalizing elevated insulin levels similar to rosiglitazone treatment. SRT 1720 treatment significantly reduces fasting blood glucose to near normal levels in Lep^ob/ob mice. SRT 1720 has ability to protect against the negative effects of diet-induced obesity in mice, and has a connection to metabolic adaptation in fatty acid and oxidative metabolism through downstream targets of SIRT1 such as PGC1α and FOXO1. SRT 1720 (50-100 mg/kg, p.o.), during emphysema development attenuates elastase-induced airspace enlargement and lung function impairment as well as reduces arterial oxygen saturation in WT mice.

相关产品：Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Epigenetics Compound Library  |  Histone Modification Research Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Antioxidant Compound Library  |  Anti-diabetic Compound Library  |  Oxygen Sensing Compound Library  |  Glutamine Metabolism Compound Library  |  Anti-Obesity Compound Library  |  Human Metabolite Library  |  Heterocyclic Compound Library  |  Highly Selective Activators Library  |  E1231  |  Cambinol  |  PROTAC Sirt2 Degrader-1  |  Resveratrol  |  SRT 1720 Hydrochloride  |  SIRT-IN-3  |  SRT 2104  |  Tenovin-6  |  Ganoderic acid D  |  Decapeptide-12  |  SIRT2-IN-11  |  AK-1  |  UBCS039  |  SIRT1-IN-2  |  CypD-IN-4  |  SIRT-IN-1  |  SIRT5 inhibitor 2  |  Sirt2-IN-1  |  SIRT1-IN-1  |  SRTCX1002  |  Nicotinamide riboside tartrate  |  Inauhzin  |  Nicotinamide-¹⁵N,¹³C₃  |  SRTCX1003  |  SIRT5 inhibitor 3  |  Sirtuin modulator 4  |  YK-3-237  |  SIRT5 inhibitor 4  |  SRT 1460  |  AC-93253

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