MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Saxagliptin

CAS No. : 361442-04-8

MCE 国际站：Saxagliptin

产品活性：Saxagliptin (BMS-477118) 是一种有效，选择性，可逆，竞争性和具有口服活性的二肽基肽酶 4 (DPP-4) (K_i = 0.6-1.3 nM) 抑制剂。Saxagliptin 可用于 2 型糖尿病的研究。

研究领域：Metabolic Enzyme/Protease

作用靶点：Dipeptidyl Peptidase

In Vitro: Saxagliptin (100 nM; 48 hours; INS-1 832/13 cells) treatment significantly induceS β-cell proliferation.
Saxagliptin (100 nM; 48 hours; INS-1 832/13 cells) treatment increases the p-AKT and active β-catenin protein levels, paralleled with the increase of c-myc and cyclin D1 protein expression.
Saxagliptin acts by preventing the degradation of glucagon-like peptide-1 and hence increases secretion of insulin and decreases secretion of glucagon.

In Vivo: Saxagliptin (1 mg/kg; for 12 weeks) treatment in high-fat diet/streptozotocin-induced diabetic rats, significant improvement in pancreas insulin secretion capacity evaluated by hyperglycemia clamp and increased β-cell to α-cell areas ratio are observed.
Saxagliptin dose-dependently inhibits plasma DPP-4 activity in Han-Wistar rats, by ~70% at 7 hours postdose with 1 mg/kg and by ~90% at 7 hours postdose with 10 mg/kg. At 24 hours postdose, ~20% and 70% inhibition, respectively, remained.

相关产品：Covalent Screening Library Plus  |  Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Metabolism/Protease Compound Library  |  FDA-Approved Drug Library  |  Drug Repurposing Compound Library  |  Covalent Screening Library  |  Anti-diabetic Compound Library  |  Ferroptosis Compound Library  |  NMPA-Approved Drug Library  |  Orally Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Drug-Induced Liver Injury (DILI) Compound Library  |  Targeted Diversity Library  |  Rare Diseases Drug Library  |  EMA-Approved Drug Library  |  Human Metabolite Library  |  Heterocyclic Compound Library  |  Off-patent Drug Library  |  Highly Selective Inhibitors Library  |  NVP-DPP728  |  Gemigliptin  |  DPP IV/hCA II-IN-1  |  Linagliptin-d₄  |  HAEGT  |  Ellipyrone A  |  2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one  |  Anagliptin hydrochloride  |  Sitagliptin phosphate  |  P32/98  |  Vildagliptin-d₇  |  Dutogliptin  |  Gosogliptin  |  Prodipine hydrochloride  |  Teneligliptin-d₄  |  Nateglinide  |  DPP-4-IN-1  |  DBPR108  |  Sitagliptin fenilalanil hydrochloride  |  Teneligliptin  |  UAMC00039 dihydrochloride  |  Sheng Gelieting  |  Puromycin aminonucleoside  |  16-Hydroxycleroda-3,13-dien-15,16-olide  |  Talabostat isomer mesylate

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。