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Indacaterol

CAS No. : 312753-06-3

MCE 国际站：Indacaterol

产品活性：Indacaterol 是一种口服有效的超长效 ADRB2 激动剂。Indacaterol 能以 β-arrestin2 依赖的方式抑制 NF-κB 活性，防止进一步的肺部损伤，并改善慢性阻塞性肺病 (COPD) 的肺功能。Indacaterol 还可用于心血管疾病的研究。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Adrenergic Receptor

In Vitro: Indacaterol (1, 2.5, 5, 10 μM; 12 h) inhibits TNF-α induced MMP-9 expression and activity in human fibrosarcoma HT1080 cells.
Indacaterol (10 μM; 6 h) inhibits TNF-α induced invasion and migration of human fibrosarcoma cells by reducing MMP-9 expression and activity.
Indacaterol (1, 2.5, 5, 10 μM; 2.5 h) inhibits TNF-α-activated IKK/NF-кB signaling in HT1080 cells.

In Vivo: Indacaterol (0.3 mg/kg; po; sinle daily for 15 weeks) shows activity of normalizing and reversing cardiac remodeling in a myocardial infarction (MI) rat model of heart failure (HF).

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