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Duvelisib

CAS No. : 1201438-56-3

MCE 国际站：Duvelisib

产品活性：Duvelisib (IPI-145) 是一种选择性 p100δ 抑制剂，作用于 p110δ, p110γ, p110β 和 p110α，IC₅₀ 分别为 2.5 nM，27.4 nM，85 nM 和 1602 nM。

研究领域：PI3K/Akt/mTOR

作用靶点：PI3K

In Vitro: PI3Kδ and PI3Kγ inhibition with Duvelisib (IPI-145) has anti-proliferative activity in primary AML cells by inhibiting the activity of AKT and MAPK. Pre-treatment of AML cells with Duvelisib inhibits both adhesion and migration of AML blasts to bone marrow stromal cells.

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