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CAS No. : 82034-46-6
MCE 国际站:Loteprednol Etabonate
产品活性:Loteprednol etabonate (LE) 是口服有效的“软”类固醇,是一种糖皮质激素。Loteprednol etabonate (LE) 具有抗炎活性,可用于验光等眼科研究。
研究领域:Immunology/Inflammation | Vitamin D Related/Nuclear Receptor | Anti-infection
作用靶点:Glucocorticoid Receptor | Bacterial | Antibiotic
In Vivo: Intravenous administration of Loteprednol etabonate (5 mg/kg) to dogs reveals a terminal half-life of 2.8 h, a volume of distribution of 3.7 L/kg, and a total body clearance of 0.9 L/h/kg. Intact loteprednol etabonate was not detectable in the urine. After oral administration of the drug (5 mg/kg) to dogs, only metabolites, but no intact drug, were found in the plasma, an indication for a high first-pass effect.
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