MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

YS-49

CAS No. : 132836-42-1

MCE 国际站：YS-49

产品活性：YS-49 是 PI3K/Akt (RhoA 的下游靶标) 的激活剂，可减少 3-甲基胆碱处理的细胞中 RhoA/PTEN 的激活。YS-49 能通过诱导血红素加氧酶 (HO-1) 来抑制血管紧张素 II (Ang II) 刺激 VSMC 细胞的增殖。YS-49 是异喹啉化合物生物碱，因能激活心脏 β-adrenoceptors 而具有强烈的正性肌力作用。

研究领域：PI3K/Akt/mTOR  |  GPCR/G Protein  |  Neuronal Signaling

作用靶点：Akt  |  PI3K  |  Angiotensin Receptor  |  Adrenergic Receptor

In Vitro: YS-49 (1-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with IC₅₀ values of 22 μM and 30 μM, respectively.
YS-49 (10-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells at the transcriptional level.

In Vivo: YS-49 (5 mg/kg; intraperitoneal injection; 8 hours; male Sprague Dawley rats) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM.

相关产品：Natural Product-like Compound Library  |  Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Kinase Inhibitor Library  |  Neuronal Signaling Compound Library  |  PI3K/Akt/mTOR Compound Library  |  Stem Cell Signaling Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Reprogramming Compound Library  |  Oxygen Sensing Compound Library  |  Anti-Cardiovascular Disease Compound Library  |  Endocrinology Compound Library  |  Glycolysis Compound Library  |  Cytoskeleton Compound Library  |  Neurotransmitter Receptor Compound Library  |  Glutamine Metabolism Compound Library  |  Neuroprotective Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Cancer Metabolism Compound Library  |  Anti-Obesity Compound Library  |  Angiogenesis-Related Compound Library  |  Glucose Metabolism Compound Library  |  Antidepressant Compound Library  |  Anti-Prostate Cancer Compound Library  |  Pain-Related Compound Library  |  Mitochondrial Protection Compound Library  |  Antihypertensive Compound Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Perphenazine-d₈ dihydrochloride  |  Desglymidodrine  |  PF-610355  |  Adrenaline sulfate  |  Umbralisib hydrochloride  |  Nadolol  |  ARC 239  |  Todralazine  |  PI3K-IN-22  |  Amibegron hydrochloride  |  N-5984  |  Zotepine  |  Paliperidone-d₄  |  LM22B-10  |  Yohimbine  |  Rigosertib sodium  |  PI3Kδ/γ-IN-2  |  Insulin Detemir  |  Clenproperol-d₇  |  (rac)-AG-205  |  (R)-(+)-Atenolol  |  Salbutamol  |  Formoterol fumarate  |  PI3kδ inhibitor 1  |  Metoprolol-d₆ tartrate  |  Irbesartan hydrochloride  |  Moprolol  |  Clonidine-d₄ hydrochloride  |  Pindolol-d₇  |  Clorprenaline

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。