MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 55778-02-4
MCE 国际站:WZ811
产品活性:WZ811 是一种具有口服活性的,高效竞争性的 CXCR4 拮抗剂。WZ811 有效抑制细胞中 CXCR4/SDF-1 (也称为 CXCL12) -介导的 cAMP 水平调节 (EC50=1.2 nM) 和 SDF-1 诱导的基质胶侵入 (EC50=5.2 nM)。
研究领域:GPCR/G Protein | Immunology/Inflammation
作用靶点:CXCR
In Vitro: WZ811 (Compound 32) is a potent CXCR4 antagonist, effectively inhibits TN14003 binding to CXCR4, with an EC50 of 0.3 nM.
WZ811 blocks SDF-1 mediated modulation cAMP levels in U87 glioma cells (EC50=1.2 nM) and Matirgel infiltration of MDA-MB-231 cells (EC50=5.2 nM).
WZ811 (1-40 μM) inhibits TF-1 and UT-7 cells proliferation in a dose dependent manner both after treatment for 24 h and 48 h. Moreover, WZ811 (5 μM) induces cell apoptosis and enhances the sensitivity of cells to docetaxel. In addition, WZ811 inhibits aggressiveness markers and induces apoptosis in chronic lymphocytic leukemia cells.
In Vivo: WZ811 (40 mg/kg, p.o.) blocks the lymphocytic leukemia cells growth on mouse xenograft models, and inhibits CXCR4/PI3K/AKT signaling pathway in mouse xenograft model of lymphocytic leukemia.
相关产品:Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Immunology/Inflammation Compound Library | Anti-Cancer Compound Library | Small Molecule Immuno-Oncology Compound Library | Endocrinology Compound Library | Orally Active Compound Library | Anti-Blood Cancer Compound Library | Targeted Diversity Library | Chemokine Compound Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | Nicotinamide N-oxide | SX-517 | AMG 487 (S-enantiomer) | TC14012 | CTCE-9908 | CXCR2 antagonist 3 | Kynurenic acid-d5 | (R,R)-CXCR2-IN-2 | IT1t dihydrochloride | NUCC-390 | Ac-Pro-Gly-Pro-OH | Vimnerixin | NBI-74330 | CXCR4 antagonist 9 | Quetmolimab | PS372424 hydrochloride | SCH 546738 | vMIP-II (1-21) | CXCR2-IN-1 | Mavorixafor | Reparixin L-lysine salt | VUF11207 fumarate | NoxaBH3 | Kynurenic acid | CXCR4 antagonist 2 | Balixafortide | Plerixafor octahydrochloride | Ladarixin
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。