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Scriptaid

CAS No. : 287383-59-9

MCE 国际站：Scriptaid

产品活性：Scriptaid 是一种组蛋白去乙酰化酶 (HDAC) 抑制剂，可用于癌症研究。Scriptaid 也是一种抗病毒药的敏化剂，可用于与爱泼斯坦-巴尔病毒 (EBV) 相关的淋巴瘤的研究。

研究领域：Cell Cycle/DNA Damage  |  Epigenetics  |  Autophagy  |  Apoptosis  |  Anti-infection

作用靶点：HDAC  |  Autophagy  |  Apoptosis  |  Influenza Virus

In Vitro: Scriptaid (1 μg/mL) treatment inhibits cell growth in breast cancer cell lines, results in increased accumulation of both acetyl H3 and acetyl H4 proteins in MDA-MB-231, MDA-MB-435, and Hs578t cells. Scriptaid also inhibits cell growth of MDA-MB-231, MDA-MB-435, and Hs578t cell lines, with IC₅₀s of 0.5-1.0 μg/mL. Scriptaid (0.1-1.0 μg/mL) induces ER and PR mRNA expression in a dose dependent manner; when it is combined with AZA, they enhance ER expression and induce a functional ER protein. Scriptaid and SAHA preferentially inhibit the Class I histone deacetylases, hdac1, 2, and 3. Scriptaid is a potent anti-T. gondii compound with low cytotoxicity, and the IC₅₀ is 39 nM. Scriptaid has atypical effects in T. gondiiinfected HS68 cells. Scriptaid inhibits the growth of HeLa cells with IC₅₀ of 2 μM at 48 h in a dose-dependent manner. Scriptaid also affects cell-cycle and apoptosis.

In Vivo: Scriptaid (3.5 μg/g mouse, i.p.) clearly inhibits tumor growth in a xenograft mouse model.

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