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Zalcitabine

CAS No. : 7481-89-2

MCE 国际站：Zalcitabine

产品活性：Zalcitabine是有效的核苷类似物逆转录酶抑制剂，用于HIV感染相关研究。

研究领域：Anti-infection

作用靶点：HIV  |  Reverse Transcriptase

In Vitro: Zalcitabine is a dideoxynucleoside antiretroviral agent that is phosphorylated to the active metabolite 2',3'-dideoxycytidine 5'-triphosphate (ddCTP) within both uninfected and HIV-infected cells. At therapeutic concentrations, ddCTP inhibits HIV replication by inhibiting the enzyme reverse transcriptase and terminating elongation of the proviral DNA chain. Zalcitabine exhibits the inhibition effect on the cellular uptake of [3H]-PAH in CHO/hOAT1 cells with an IC₅₀ value of 1.23 mM. Furthermore, the cellular uptake of zalcitabine increased threefold with the enhancement of hOATI activity in CHO/hOAT1 cells.

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