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DMAT

CAS No. : 749234-11-5

MCE 国际站：DMAT

产品活性：DMAT 是一种有效的，特异性的 CK2 抑制剂，IC₅₀ 值为 130 nM。

研究领域：Cell Cycle/DNA Damage  |  Stem Cell/Wnt

作用靶点：Casein Kinase

In Vitro: DMAT (1 μM-2.5 μM) DMAT is more efficient in killing antiestrogen resistant cells than parental antiestrogen sensitive MCF-7 cells. DMAT-induced cell death of antiestrogen resistant cells is mediated by caspases. DMAT inhibits CK2 activity but the inhibition is similar in the three cell lines, MCF-7, TAMR-1 and 182R-6.
DMAT has effects on H295R cell proliferation at concentrations of 10^-4 and 10^-5mol/Las compared with the control. DMAT (100 μM) significantly increases apoptosis of H295R cells. DMAT (1 nM-1 μM) significantly decreases aldosterone release into supernatants of 72-h H295R cell cultures as compared with the control.
DMAT also inhibits PIM1 by a mechanism which is competitive with respect to ATP, and it is a powerful inhibitor of kinases other than CK2.

In Vivo: DMAT application in vivo reduces tumor growth in a xenotransplant model by interference with tumor cell proliferation. Biochemical parameters and histology following DMAT administration revealed no alterations in liver tissue.

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