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CAS No. : 71439-68-4
MCE 国际站:Bisantrene dihydrochloride
产品活性:Bisantrene dihydrochloride 是高效的抗癌剂,它通过影响 DNA 插入发挥细胞毒性。Bisantrene dihydrochloride 靶向真核生物的拓扑异构酶 II。Bisantrene dihydrochloride 是MDR1 的底物。
研究领域:Cell Cycle/DNA Damage
作用靶点:Topoisomerase
In Vitro: Bisantrene dihydrochloride promots DNase I cleavage at oligopurine-oligopyrimidine tracts and slightly reduces the cleavage activity at alternating purine-pyrimidine sequences.Bisantrene dihydrochloride is an inhibitor of [3H]uridine incorporation into RNA and [3H]thymidine incorporation into DNA.
In Vivo: Bisantrene dihydrochloride is an antitumor agent active against a number of experimental tumors, including P388 leukemia, L1210 leukemia, Lieberman plasma cell tumor, B16 melanoma, colon tumor 26, and Ridgway osteogenic sarcoma.Bisantrene dihydrochloride is effective over a dose range of 1.56 to 150 mg/kg depending upon the frequency, route, and schedule of the treatment and the tumor model used.Bisantrene dihydrochloride (25, 50 and 100 mg/kg; i.p.; once) pretreats with macrophages shows antitumor effect to mice with P815 tumor cells injection.Bisantrene dihydrochloride (10-150 mg/kg; i.v.; once) dose-dependently induces leukopenia in Neo mice. B cells and macrophages are targets for bisantrene dihydrochloride toxicity.
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