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CAS No. : 54824-17-8
MCE 国际站:Mitonafide
产品活性:Mitonafide (NSC 300288) 是一种细胞生长抑制剂。Mitonafide 通过嵌入 DNA 而与双链 DNA 结合,抑制 DNA 和 RNA 的合成。Mitonafide 是一种抗肿瘤剂,可用于癌症研究,如非小细胞肺癌 (NSCLC)、白血病。
研究领域:Cell Cycle/DNA Damage
作用靶点:DNA/RNA Synthesis
In Vitro: Mitonafide inhibits DNA and RNA synthesis and induces single-strand breaks in the DNA of chinese hamster ovary cells.
The incubation of Mitonafide with rat liver microsomes and NADPH under anaerobic conditions results in the formation of a metabolite identified as 5-aminomitonafide.
Mitonafide (25, 50 μM, 1 h) induces single-stand breaks in the DNA of L1210 cells.
Mitonafide (10-100 μM) exhibits cytotoxic effect in the HOP-62 lung cell line.
In Vivo: Mitonafide (0.5 and 1 mg/kg, i.p., 1-7 days) shows antitumoral potency in S-180 bearing mice.
Mitonafide (5 mg/kg, i.p., twice a day) shows anticancer activity in HepG2 xenograft model.
Mitonafide (single i.p. injection, S-180 bearing mice) shows the LD50 value of 10.0 mg/kg.
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