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Tivozanib

CAS No. : 475108-18-0

MCE 国际站：Tivozanib

产品活性：Tivozanib (AV-951; KRN951) 是一种有效的、选择性的、具有口服活性的 VEGFR 酪氨酸激酶 抑制剂，对 VEGFR-1、VEGFR-2、VEGFR-3的 IC₅₀ 值分别为 0.21、0.16、0.24 nM。Tivozanib 抑制肿瘤组织中的血管生成和血管通透性，并显示出抗肿瘤活性。Tivozanib 具有研究转移性肾细胞癌 (RCC) 的潜力。

研究领域：Protein Tyrosine Kinase/RTK

作用靶点：VEGFR

In Vitro: Tivozanib inhibits the phosphorylation of VEGFR-1, VEGFR-2 and VEGFR-3.

In Vivo: Tivozanib (1 mg/kg; p.o.; 14 days) suppresses the development of CNV lesions and leds to a significant regression of established CNV, reducing the affected areas by 67.7%.

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