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Bosutinib

CAS No. : 380843-75-4

MCE 国际站：Bosutinib

产品活性：Bosutinib是一种口服Src/Abl酪氨酸激酶抑制剂，IC50分别为1.2 nM和1 nM。

研究领域：Protein Tyrosine Kinase/RTK  |  Autophagy

作用靶点：Src  |  Bcr-Abl  |  Autophagy

In Vitro: Bosutinib (SKI-606) is an active inhibitor of Bcr-Abl in several chronic myelogenous leukemia cell lines, with IC₅₀ values in the low nanomolar range.

In Vivo: Bosutinib (oral gavage; 75 mg/kg twice daily or 150 mg/kg once daily) has activity against human KU812 xenografts in nude mice. Bosutinib (150 mg/kg; once daily, 5 days weekly) has activity against syngeneic Bcr-Abl WT and mutantBa/F3 xenografts.

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