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CAS No. : 706808-37-9
MCE 国际站:Belatacept
产品活性:Belatacept (BMS 224818) 是一种选择性 T 细胞共刺激 (T-cell costimulation) 阻滞剂。Belatacept 与 CD 80/86 配体结合而抑制 CD-28 介导的 T 细胞共刺激。Belatacept 可用于器官移植免疫抑制的研究。
研究领域:Others
作用靶点:Others
In Vitro: Belatacept (0-5 mg/mL, 1 h) inhibits T-cell proliferation in a dose-dependent manner.
Belatacept (500 ng/mL, 7 days) enhances predominance of effector-memory T-cells after allogeneic stimulation.
Belatacept (100, 500 ng/mL, 7 days) has no effect on differentiation and allogeneic IFNγ production of isolated effector-memory T cells.
Belatacept (10 μg/mL, 1 h) does not inhibit follicular T Cell-dependent B-Cell differentiation.
Belatacept (40 μg/mL, 10 days) reduces plasmablast differentiation, Ig production, and the major transcription factor Blimp-1 in a T cell-independent manner.
Belatacept (40 μg/mL, 30 min) induces activation of the STAT3 transcription factor in stimulated B cells and reduced the expression of CD86.
In Vivo: Belatacept (intraperitoneal injection, 60 mg/kg) inhibits ABMR (Antibody-Mediated Rejection), and inhibits acute rejection when combined with BTLA (B and T lymphocyte attenuator) overexpression therapy.
Belatacept (intravenous injection, 20 mg/kg) displays immunosuppressive activities in monkeys immunized with sheep red blood cell.
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