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CAS No. : 20329-98-0
MCE 国际站:(E)-3,4,5-Trimethoxycinnamic acid
产品活性:(E)-3,4,5-Trimethoxycinnamic acid (TMCA) 是一种被多甲氧基取代的肉桂酸。(E)-3,4,5-Trimethoxycinnamic acid 是一种口服有效的 GABAA/BZ 受体激动剂。(E)-3,4,5-Trimethoxycinnamic acid 与 5-HT2C 和 5-HT1A 受体具有良好的结合亲和力,其 IC50 值分别为 2.5 和 7.6 μM。(E)-3,4,5-Trimethoxycinnamic acid 具有抗惊厥和镇静活性。(E)-3,4,5-Trimethoxycinnamic acid 可用于失眠、头痛、癫痫的研究。
研究领域:Membrane Transporter/Ion Channel | Neuronal Signaling | GPCR/G Protein
作用靶点:GABA Receptor | 5-HT Receptor
In Vitro: (E)-3,4,5-Trimethoxycinnamic acid (10 μg/mL, 1 h) increases the expressions of GAD65 and γ-subunit of GABAA receptors in the cerebellar granule cells.
(E)-3,4,5-Trimethoxycinnamic acid (0-10 μg/mL, 1 h) shows a significant increase in Cl- influx.
In Vivo: (E)-3,4,5-Trimethoxycinnamic acid (0-20 mg/kg, IP, once) shows anti-seizure effects.
(E)-3,4,5-Trimethoxycinnamic acid (0-10 mg/kg, Orally, once) enhances hypnotic effects in pentobarbital-treated mice.
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