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CAS No. : 550-10-7
MCE 国际站:Hydrocotarnine
产品活性:Hydrocotarnine 是一种 Cbl 抑制剂,可导致结肠炎炎症小体介导的 IL-18 分泌。Hydrocotarnine 能增加细胞糖酵解代谢中的 GLUT1 表达和对葡萄糖的摄取。Hydrocotarnine 在癌症研究中具有镇痛作用。
研究领域:Metabolic Enzyme/Protease | Immunology/Inflammation
作用靶点:E1/E2/E3 Enzyme | Interleukin Related
In Vitro: Hydrocotarnine is an analgesic agent (CRIN-2), with the patent ID of WO2011160016A2.
Hydrocotarnine (10 μM; 1 h) elevates the secretion of IL-1β and IL-18, and (0.1-10 μM; 1 h) increases the global level of tyrosine-phosphorylated proteins in THP-1 cells.
Hydrocotarnine (50 μM; 0-100 min) increases the glycolytic capacity and glycolytic reserve capacity in THP-1-derived macrophages.
Hydrocotarnine (50 μM; 16 h) inhibits Cbl and increases the total GLUT1 protein in THP-1-derived macrophages.
Hydrocotarnine is known to enhance the analgesic effect of opioids, and alleviates cancer pain.
In Vivo: Hydrocotarnine (10 mg/kg/d; i.p.; 9 d) shows inhibitory effect on Cbl and results in increasing IL-18 levels, indicating that NLRP3 inflammasome activation is enhanced in mice.
Hydrocotarnine (10 mg/kg/d; i.p.; 9 d) protects mice from DSS-induced colitis, with low scores of pathological evaluation of inflammation, epithelial defects, and crypt atrophy.
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