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CC214-2

CAS No. : 1228012-18-7

MCE 国际站：CC214-2

产品活性：CC214-2 是一种口服有效的 mTOR 激酶抑制剂。CC214-2 靶向 mTORC1 (pS6) 和 mTORC2 (pAktS473)。CC214-2 诱导自噬，自噬即是结核病宿主定向治疗 (HDT) 的潜在靶点。CC214-2 对结核病 (TB) 表现出协同抑菌和杀菌活性，并能够缩短产生效力的时间。CC214-2 还抑制雷帕霉素 (HY-10219) 耐药信号，并在体外和体内抑制胶质母细胞瘤的生长。

研究领域：PI3K/Akt/mTOR  |  Autophagy

作用靶点：mTOR  |  Autophagy

In Vivo: CC214-2 (25 mg/kg, 50 mg/kg; po; once daily for 21 days) results tumor volume reductions in PC3 tumor xenograft model.
CC214-2 (30 mg/kg, 100 mg/kg; po; single dose) inhibits both mTORC1 (pS6) and mTORC2 (pAktS473) in vivo for at least 8 and 24 h, respectively.
CC214-2 (30 mg/kg; po) reduces M. tuberculosis CFU numbers and prevents mortality in mice with Chronic M. tuberculosis infection.
CC214-2 (50 mg/kg; po; once daily for 6 days) significantly reduces the growth of mouse U87EGFRvIII flank xenografts.
CC214-2 (100 mg/kg; po; once every 2 days for 6 days) inhibits mTORC1 and mTORC2 signaling in an intracranial glioblastoma model.

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