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CAS No. : 849669-54-1
MCE 国际站:AQX-016A
产品活性:AQX-016A 是一种口服有效的 SHIP1 激动剂。AQX-016A 可以在体外激活重组 SHIP1 酶并刺激 SHIP1 活性。AQX-016A 还可抑制 PI3K 通路和 TNFa 的产生,可用于各种炎症疾病的研究。
研究领域:Metabolic Enzyme/Protease | PI3K/Akt/mTOR | Apoptosis
作用靶点:Phosphatase | PI3K | TNF Receptor
In Vitro: AQX-016A (5 μg/mL, 30 min) inhibits the PI3K-mediated increase in intracellular PIP3 levels, and reduces PIP3 levels through activation of a 5 'phosphatase enzyme.
AQX-01 6A (0-5 μg/mL, 30 min) inhibits LPS-induced PKB phosphorylation in a SHIP dependent manner.
AQX-016A (0-5 μg/mL, 2 h) significantly inhibits TNFa in both J774 and peritoneal macrophages at both 1 and 5 μg/mL.
AQX-016A (0-6 μg/mL, 30 min) requires SHIP to maximally inhibit TNFa production in BMDM, selectively inhibits TNF production from SHIP1+/+ but not SHIP1-/- macrophages.
AQX-016A (0-5 μg/mL, 0-90 min) inhibits TNFa translation.
AQX-016A (0-15 μM, 30 min) increases SHIP1 enzyme activity in vitro and in intact cells, inhibits macrophage and mast-cell activation.
AQX-016A (15 μM, 30 min) inhibits immune cell activation, and inhibits PI3K-dependent macrophage and mast-cell responses in a SHIP-dependent manner.
In Vivo: AQX-016A (20 mg/kg, Orally, once) significantly inhibits plasma TNFa levels, and inhibits inflammation in a mouse model endotoxemia.
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