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CAS No. : 26615-21-4
MCE 国际站:Zotepine
产品活性:Zotepine,一种抗精神病剂,是有效的 5-HT2A,5-HT2C,组胺 H1,α1-adrenergic 和多巴胺 D2 受体拮抗剂,Kd 值分别为 2.6 nM、3.2 nM、3.3 nM、7.3 nM 和 8 nM。Zotepine 在体内表现出抗抑郁和抗焦虑作用。
研究领域:GPCR/G Protein | Neuronal Signaling | Immunology/Inflammation
作用靶点:5-HT Receptor | Histamine Receptor | Adrenergic Receptor | Dopamine Receptor
In Vitro: Zotepine shows multiple antagonistic profiles with strong affinities to α1-adrenergic, α2-adrenergic, Dopamine D2, Histamine H1, Muscarinic, 5-HT1A, 5-HT1D, 5-HT2A, and 5-HT2C receptors, with Kds of 7.3, 180, 8, 3.3, 330, 280, 80, 2.6, 3.2 nM, respectively.
In Vivo: Zotepine (1-3 mg/kg; a single i.p.) dose-dependently increases noradrenaline, dopamine, GABA, and glutamate release without affecting 5-HT levels in the medial prefrontal cortex of rats.
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