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NAAD sodium

CAS No. : 104809-30-5

MCE 国际站：NAAD sodium

产品活性：NAAD sodium (Deamido nad sodium) 是一种功能性 NAD⁺ 前体，是谷氨酰胺依赖性 NAD⁺ 合成酶的底物。NAAD sodium 用于研究烟酸单核苷酸腺苷酸转移酶的结构。

研究领域：Metabolic Enzyme/Protease

作用靶点：Endogenous Metabolite

In Vitro: In peripheral blood mononuclear cells (PBMC), NAAD sodium is only expected to be produced in biosynthesis of NAD⁺ from tryptophan and NA2, was elevated from less than 20 nM to as high as 0.91 μM.
Nicotinamide adenine dinucleotide synthetases (NADS) catalyze the amidation of nicotinic acid adenine dinucleotide (NAAD) to yield the enzyme cofactor nicotinamide adenine dinucleotide (NAD).

In Vivo: In mice, when nicotinic acid (NA) is provided by oral gavage, liver NA peaked (340 pmol/mg) in 15 min. Hepatic NA appearance is followed by an expected peak of 220 NAAD sodium at 1 h post gavage and a rise in hepatic NAD⁺ from 990 baseline to 2200 at 2 h.
NAAD sodium is reported in mouse liver when 500 mg/kg of radioactive nicotinamide (Nam) is injected intraperitoneally (IP) into the body cavity of mice. However, NAAD sodium is observed in kidneys, ovaries, lung, heart and brain in addition to liver in mice IP-injected with 500 mg/kg of NA but not Nam.

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