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CAS No. : 2863-04-9
MCE 国际站:Thymidine 3',5'-disphosphate
产品活性:Thymidine 3',5'-disphosphate (Deoxythymidine 3′,5′-diphosphate; pdTp) 是一种选择性的葡萄球菌核酸酶和含有 1 的都铎结构域 (SND1,miRNA 调控复合体 RISC 亚基) 的小分子抑制剂,可抑制 SND1 活性。Thymidine 3',5'-disphosphate 在体内表现出抗肿瘤活性。
研究领域:Apoptosis
作用靶点:Apoptosis
In Vitro: Thymidine 3',5'-disphosphate (200 µM; 18 h) significantly reduces the expression level of p65 and p65 nuclear translocation in WT and Alb/SND1 (specific transgenic mouse overexpressing SND1) hepatocytes by inhibiting staphylococcal nuclease and tudor domain containing 1 (SND1) enzyme activity. Thymidine 3',5'-disphosphate inhibits the spherical formation of WT and Alb/SND1 hepatocytes.
In Vivo: Thymidine 3',5'-disphosphate (0.8 mg/kg or 1.6 mg/kg; i.p. or i.v.; twice a week for 4 weeks) significantly inhibits xenotransplantation of human hepatocellular carcinoma in WT B6/CBA mice.
Thymidine 3',5'-disphosphate (0.8, 0.16 and 0.32 mg/kg; s.c.; twice a week for 4 weeks) inhibits tumor proliferation, inflammatory reaction and the expression of tumor initiating cells (TIC) markers in adult male NSG mice. Thymidine 3',5'-disphosphate up-regulates the expression of apoptosis and selective tumor suppressor genes.
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