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CAS No. : 2364554-48-1
MCE 国际站:Aficamten
产品活性:Aficamten (CK-274) 是一种新型心肌肌球蛋白 (cardiac myosin)抑制剂,IC50 为 1.4 μM。Aficamten 可用于肥厚型心肌病 (HCM) 的研究。
研究领域:Cytoskeleton
作用靶点:Myosin
In Vivo: Aficamten is a next-generation cardiac myosin inhibitor that provides a projected human half-life appropriate for once a day dosing, reaching steady state within two weeks, and demonstrates a wide therapeutic window in vivo with a clear PK/PD relationship.
Aficamten exhibits moderate oral bioavailability (mouse 98%, rat 55%, rat 58%,rat 79%, dog 45%, monkey 41%) following oral administration (mouse 1 mg/kg, rat 2 mg/kg, rat 3 mg/kg, rat 8 mg/kg, dog 1 mg/kg and monkey 1 mg/kg).
Aficamten exhibits terminal elimination half-lives (mouse 4.5 h, rat 3.0 h, dog 33.8 h and, monkey 8.1 h) following intravenous administration (mouse 0.5 mg/kg, rat 1 mg/kg, dog 1 mg/kg and monkey 1.0 mg/kg).
相关产品:Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Clinical Compound Library | Drug Repurposing Compound Library | Anti-Cardiovascular Disease Compound Library | Cytoskeleton Compound Library | Heterocyclic Compound Library | Myosin V-IN-1 | ATM-3507 trihydrochloride | Omecamtiv mecarbil-d8 | HA-100 hydrochloride | Danicamtiv | Blebbistatin | Mavacamten | MT-134 | JB002 | 16-38-Thymosin β4 (cattle) (TFA) | para-Nitroblebbistatin | Kemptamide | MLCK inhibitor peptide 18 | W-7 hydrochloride | BTS | JB062 | Pentachloropseudilin | Sevasemten | MPH-220 | ML-7 hydrochloride | Para-aminoblebbistatin | Omecamtiv mecarbil | JB061 | ML-9 Free Base
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