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CAS No. : 53984-36-4
MCE 国际站:3-Chloro-5-hydroxybenzoic acid
产品活性:3-Chloro-5-hydroxybenzoic acid 是一种有效的、具有口服活性的,选择性乳酸受体 GPR81 激动剂,对人 GPR81 的 EC50 为 16 μM。3-Chloro-5-hydroxybenzoic acid 在肥胖小鼠模型中显示出良好的体内脂肪分解作用。
研究领域:Others
作用靶点:Others
In Vitro: 3-Chloro-5-hydroxybenzoic acid shows potency against human (EC50=16 μM), monkey (EC50=17 μM), dog (EC50=67 μM), rat (EC50=7 μM), mouse (EC50=22 μM), and hamster GPR81 (EC50=27 μM).
In Vivo: 3-Chloro-5-hydroxybenzoic acid (30, 100, and 300 mg/kg; PO in overnight fasted C57Bl6/J mice fed high fat chow for 10 weeks) shows significant reductions in free fatty acids at all doses tested, resulting in a minimum efficacious dose of 30 mg/kg.
Pharmacokinetic Parameters of 3-Chloro-5-hydroxybenzoic acid in Mice.
dose (mg/kg) | tmax (h) | AUCinf (h ng/mL) | Cmax (ng/mL) | Cmax (μM) | t1/2 (h) |
30 | 0.5 | 9356 | 11689.50 | 67.2 | 1.47 |
100 | 0.5 | 51312 | 55252.80 | 341.9 | 1.10 |
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