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CAS No. : 798577-91-0
MCE 国际站:Avanbulin
产品活性:Avanbulin (BAL27862) 是一种有效的秋水仙碱位点结合的微管蛋白 (tubulin) 装配抑制剂。Avanbulin 在 37 °C 抑制微管蛋白组装 (IC50=1.4 μM)。Avanbulin 与微管蛋白结合的 Kd 值为 244 nM。Avanbulin 可用于癌症和细胞分裂的研究。
研究领域:Cell Cycle/DNA Damage | Cytoskeleton
作用靶点:Microtubule/Tubulin
In Vitro: Avanbulin (0-4 μM) binds to tubulin in the site as Colchicine with an apparent Kd value of 244 nM..
Avanbulin (50 μM; 0, 10, 20, 30, 60 min) induces the proteolysis of tubulin.
Avanbulin (33 nM; 0, 10, 20, 30, 60 min; HeLa-tubGFP cells) collapses the mitotic spindle and forms the tiny tubulin aggregates.
Avanbulin does not induce the formation of tubulin oligomers.
Avanbulin induces growth inhibition of 23 tumor cell lines with a median relative IC50 of 13.8 nM (96 hours) .Avanbulin (6 nM and 20 nM) inhibits the migration of GBM6 and GBM9 cells.
Avanbulin (6 nM and 20 nM; GBM6-shEB1 and GBM6-sh0 cells) triggers astrocytic differentiation of GBM6 in an EB1-dependent manner.
Avanbulin (12 nM; 4 h) reduces kinetochore-microtubule (KT–MT) occupancy of MG132(10 μM; 2h) treated hTert-RPE1 eGFP-α-tubulin cells.
Avanbulin (12 nM; 4 h) reduces average inter-KT distances of cells, shows intact spindle morphology, and lacks obvious chromosome alignment defects.
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