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PT-262

CAS No. : 86811-36-1

MCE 国际站：PT-262

产品活性：PT-262 是一种有效的 ROCK 抑制剂，IC₅₀ 值约为 5 μM。PT-262 诱导线粒体膜电位的丧失并提高 caspase-3 的激活和细胞凋亡。PT-262 通过 p53 独立途径抑制 ERK 和 CDC2 磷酸化。PT-262 阻断细胞骨架功能和细胞迁移。PT-262 具有抗癌活性。

研究领域：Cell Cycle/DNA Damage  |  Stem Cell/Wnt  |  Cytoskeleton  |  TGF-beta/Smad  |  MAPK/ERK Pathway  |  Apoptosis

作用靶点：ROCK  |  ERK  |  CDK  |  Apoptosis

In Vitro: PT-262 (5-40 μM; 24 h) induces cytotoxicity and proliferation inhibition in human lung cancer cells.
PT-262 (2-20 μM; 4-24 h) induces caspase-3 activation, mitochondrial dysfunction and apoptosis in lung cancer cells.
PT-262 (10-20 μM; 24 h) induces the accumulation of G2/M phases in both the p53-wild type and p53-null lung cancer cells, and inhibits the phosphorylation of CDC2 proteins.
PT-262 (0-10 μM; 24 h) represses ERK phosphorylation in lung cancer cells.
PT-262 (2 μM; 24 h) induces the cytoskeleton alteration and cell elongation in lung carcinoma A549 cells.
PT-262 (2-10 μM; 6 h) significantly blocks the cell migration in a concentration-dependent manner.

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