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8-Epixanthatin

CAS No. : 30890-35-8

MCE 国际站：8-Epixanthatin

产品活性：8-Epixanthatin 是一种潜在的秋水仙碱结合位点抑制剂，从Xanthium chinese Mill 中分离得到。8-Epixanthatin 可以抑制 STAT3 的激活，诱导细胞凋亡( apoptosis)，具有抗肿瘤活性。

研究领域：JAK/STAT Signaling  |  Stem Cell/Wnt  |  Apoptosis

作用靶点：STAT  |  Apoptosis

In Vitro: 8-Epixanthatin(2-20 μM, 12 h) inhibits DU145 cell proliferation and p-STAT3 levels of DU145 cell in a dose-dependent manner with an IC₅₀ value of 3.2 μM.
8-Epixanthatin can inhibit STAT3 activation and cell proliferation by inducing ROS production in DU145 cancer cells.

In Vivo: 8-Epixanthatin (i.p., 50 mg/kg, 5 days per week for 25 days) can inhibit tumor growth through STAT3 inactivation, the tumor volume of mice was reduced by 40.1%, the tumor weight was reduced by 40.0%, and the p-STAT3 level in the tumor was significantly reduced in the mouse xenograft model of DU145 cells.

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