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MCE 国际站:Poly (I:C):Kanamycin (1:1) (sodium)
产品活性:Poly (I:C):Kanamycin (1:1) sodium 是 Poly (I:C) (HY-135748) 和 Kanamycin (HY-16566) 的等比例复合物。Poly(I:C) sodium 是双链 RNA 的合成类似物,是一种 TLR3 和视黄酸诱导型基因 I 受体 (RIG-I 和 MDA5) 的激动剂。Poly(I:C) sodium 可以用作疫苗佐剂,增强先天性和适应性免疫反应,并诱导癌细胞凋亡。Kanamycin 是一种具有口服活性的抗菌剂(革兰氏阴性/阳性细菌),可抑制易位并通过与 70 S 核糖体亚基结合引起错误编码。Kanamycin 对结核分枝杆菌(敏感和耐药)和肺炎克雷伯菌均表现出良好的抑制活性,可用于结核病和肺炎的研究。
研究领域:Immunology/Inflammation | Apoptosis
作用靶点:Toll-like Receptor (TLR) | Apoptosis
In Vitro: Poly (I:C) sodium (20 ng/mL; 24 hours; WM793, WM278, WM239A, WM9 and 1205Lu cells) treatment strongly reduces viability from 100% in controls to 20%–50% within 24 hours.
Poly (I:C) sodium (200 ng/mL; 24 hours; 1205Lu cells) treatment induces apoptosis in 1205Lu cells.
Poly (I:C) sodium (3 ng/mL; 24 hours; 1205Lu cells) treatment induces IFN-β expression in melanoma cells. Silencing of RIG-I and MDA-5 confirmed that induction of IFN-β by Poly (I:C) sodium required RIG-I and MDA-5, respectively, and that required IPS-1.
Poly (I:C) sodiumd (5 ng/mL; 24 hours; 1205Lu cells) treatment reveals active subunits of caspase-9 and caspase-8 in melanoma cells.
Kanamycin (0.1-100 μg/mL; 2 weeks) exhibits good antibacterial activity (MIC=1-5 μg/mL) to various strains of mycobacteria in vitro.
In Vivo: Poly (I:C) sodium treatment inhibits tumor growth in NOD/SCID immunodeficient mice injected with 1205Lu cells. The level of human DNA is 50% lower in mice treated with Poly (I:C) sodium.
Kanamycin (2, 4 mg/kg; s.c.; once daily, 6 times a week for 3 weeks) inhibits growth of bovine tubercle bacilli in lung and spleen of mice.
Kanamycin (1.25, 5 mg/kg; s.c.; single (at 3 h after infection)) inhibits the multiplication of K. pneumonia DT-S in lung, trachea, and blood of mice and in proportion to the dose administration, and also increases the survival rate of mice.
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