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CAS No. : 666860-59-9
MCE 国际站:SSR411298
产品活性:SSR411298 是一种具有口服活性、选择性和可逆的脂肪酸酰胺水解酶 (FAAH) 抑制剂。SSR411298 具有用于创伤后应激障碍研究的潜力。
研究领域:Metabolic Enzyme/Protease | Neuronal Signaling
作用靶点:FAAH
In Vitro: SSR411298 (0.1, 1, 10, 100, 1000, 10000 nM) inhibits mouse brain FAAH in a concentration-dependent manner.
SSR411298 produces maximal inhibition of FAAH between 0.3 and 30 mg/kg in the ex-vivo experiment.
In Vivo: SSR411298 (0.3, 1, 3 mg/kg; p.o.; twice a day during 2 days; 60 minutes before pretest, immediately after, and 60 minutes before the second session of testing) produces robust antidepressant-like activity in the rat forced-swimming test and in the mouse chronic mild stress model, restoring notably the development of inadequate coping responses to chronic stress in male Wistar rats weighing 235-290 g.
SSR411298 (0.3, 1, 3, 10 mg/kg; po; single dose; two hours prior to sacrifice) produces a significant global increase of tissular AEA, PEA and OEA levels in the hippocampus, but not of 2-AG levels.
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