MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

OSS_128167

CAS No. : 887686-02-4

MCE 国际站：OSS_128167

产品活性：OSS_128167 是一种有效的选择性沉默调节蛋白 6 (SIRT6) 抑制剂，对 SIRT6，SIRT1 和 SIRT2 的 IC₅₀ 分别为 89 μM，1578 μM 和 751 μM。OSS_128167 具有抗 HBV 活性，可抑制 HBV 的转录和复制。OSS_128167 具有抗癌，抗炎和抗病毒作用。

研究领域：Cell Cycle/DNA Damage  |  Epigenetics  |  Anti-infection

作用靶点：Sirtuin  |  HBV

In Vitro: OSS_128167 (Compound 9; 100 μM; 0-24 hours; BxPC3 cells) treatment increases H3K9 acetylation. And also increases GLUT-1 expression in BxPC-3 cells.
?OSS_128167 (Compound 9) effectively blunts phorbol myristate acetate (PMA)-induced TNF-α secretion in cultured BxPC-3 cells. OSS_128167 increases glucose uptake in cells.
?OSS_128167 (100 μM; 96 hours; HepG2.2.15 and HepG2-NTCP cells) treatment significantly decreaseS HBV core DNA and 3.5-Kb RNA levels. OSS_128167 treatment also inhibits hepatitis B surface antigen (HBsAg) and hepatitis B envelope antigen (HBeAg) secretions, as well as HBsAg expression in cell lysates.
?OSS_128167 (200 μM) induces chemosensitization in primary multiple myeloma (MM) cells (NCI-H929), as well as in melphalan-resistant (LR-5) and doxorubicin-resistant (Dox40) MM cell lines.

In Vivo: OSS_128167 (50 mg/kg; intraperitoneal injection; every 4 days; for 12 days; male HBV transgenic mice) treatment markedly suppresses the level of HBV DNA and 3.5-Kb RNA in HBV transgenic mice.

相关产品：Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Cell Cycle/DNA Damage Compound Library  |  Epigenetics Compound Library  |  Immunology/Inflammation Compound Library  |  Histone Modification Research Compound Library  |  Anti-Cancer Compound Library  |  Antiviral Compound Library  |  Anti-Aging Compound Library  |  Antioxidant Compound Library  |  Reprogramming Compound Library  |  Oxygen Sensing Compound Library  |  Glutamine Metabolism Compound Library  |  Anti-Blood Cancer Compound Library  |  Heterocyclic Compound Library  |  Highly Selective Inhibitors Library  |  E1231  |  Cambinol  |  FNC-TP  |  Tuvirumab  |  PROTAC Sirt2 Degrader-1  |  Bicyclol  |  Catalpol  |  (5S,8R)-HBV-IN-10  |  Resveratrol  |  Glycosmisic acid  |  RO8191  |  Adefovir-d₄  |  SRT 1720 Hydrochloride  |  Swertianolin  |  Tiviciclovir  |  SIRT-IN-3  |  (1R)-Tenofovir amibufenamide  |  2'-Deoxy-L-adenosine  |  HBV-IN-13  |  AB-423  |  Brain Derived Basic Fibroblast Growth Factor (1-24)  |  Pseudolaric Acid B  |  SRT 2104  |  Canocapavir  |  Tenovin-6  |  Ganoderic acid D  |  RG7834  |  Periglaucine B  |  HBV-IN-10  |  Decapeptide-12

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。