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CAS No. : 1050480-30-2
MCE 国际站:PhiKan 083 hydrochloride
产品活性:PhiKan 083 hydrochloride 是一种咔唑衍生物,可以稳定 p53 的突变体 Y220C,Kd 值为 167 μM,在 Ln229 细胞中,相对亲和力 (Kd) 为 150 μM;PhiKan 083 可用于癌症研究。
研究领域:Apoptosis
作用靶点:MDM-2/p53
In Vitro: PhiKan 083 is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM, shows a relative binding affinity (Kd) of 150 μM for p53Y220C in Ln229 cells.
PhiKan 083 slows down its thermal denaturation rate.
PhiKan 083 (125 μM, 48 hours) reduces the cell viability of engineered variants of Ln229 cells.
PhiKan 083 (100 μM) in conbination with NSC 123127 (1 μM) enhances the pro-apoptotic activity in all variants of Ln229 cells (p53wt, p53Y220C, p53G245S, p53R282W).
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