MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

NSC117079

CAS No. : 500363-63-3

MCE 国际站：NSC117079

产品活性：NSC117079是新型的 PHLPP 抑制剂。

研究领域：Metabolic Enzyme/Protease

作用靶点：Phosphatase

In Vitro: NSC-117079 at 30 μM induces neutrophil adhesion to plated fibrinogen from 9.0±2.4% to 27.0±8.0% and enhanced neutrophil adhesion caused by 50 ng/mL GM-CSF from 22.9±6.0% to 47.6±10.9%. Neutrophil adhesion is followed by neutrophil transendothelial migration. Results suggest that PHLPP inhibitor NSC-117079 is effective in preventing Akt from dephosphorylation in neutrophils, and Akt phosphatase PHLPP serves to attenuate neutrophil adhesion but not migration.

In Vivo: A single intraarticular injection of the Phlpp inhibitor NSC117079 attenuates mechanical allodynia and slows articular cartilage degradation in joints with a destabilized meniscus. Animals treated with the Phlpp inhibitor seven weeks after injury maintain normal activity levels, while those in the control group travel shorter distances and are less active three months after the joint injury. NSC117079 also increases production of cartilage extracellular matrix components (glycosaminoglycans and aggrecan) in over 90% of human articular cartilage explants from osteoarthritis patients and increased phosphorylation of Phlpp1 substrates (AKT2, ERK1/2 and PKC) in human articular chondrocytes.

相关产品：Natural Product-like Compound Library  |  Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Metabolism/Protease Compound Library  |  Targeted Diversity Library  |  BN82002  |  Rubrofusarin 6-O-β-D-glucopyranoside  |  RMC-3943  |  GNF362  |  MY10  |  D-erythro-Sphingosine  |  AS1949490  |  NTPDase-IN-1  |  SHP099 hydrochloride  |  Ertiprotafib  |  Trimyristin--d₁₅  |  SMAP-2  |  cyt-PTPε Inhibitor-1  |  Raphin1 acetate  |  Calyculin A  |  Endothall  |  Razuprotafib  |  Icerguastat  |  Methyl pseudolarate B  |  5-FAM-Alkyne  |  Calcium glycerophosphate  |  Trichomide A  |  PTP1B-IN-21  |  PFKFB3-IN-2  |  CCT007093  |  BVT948  |  L-690330 hydrate  |  SPI-112  |  EWP 815  |  PTPN2/1-IN-1

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。