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CAS No. : 2319837-99-3
MCE 国际站:AZ7550 Mesylate
产品活性:AZ7550 Mesylate 是 AZD9291 的一种活性代谢物,AZ7550 抑制 IGF1R 活性,IC50 为 1.6 μM。
研究领域:JAK/STAT Signaling | Protein Tyrosine Kinase/RTK | Metabolic Enzyme/Protease
作用靶点:EGFR | IGF-1R | Drug Metabolite
In Vitro: AZ7550 (Compound 28) appeares to offer a broadly similar potency and selectivity profile to the parent compound AZD9291. AZ7550 inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo with IC50s of 45, 26, and 786 nM, respectively. AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 with GI50s of 19, 15, and 537 nM, respectively.
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