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CAS No. : 1964515-43-2
MCE 国际站:LDH-IN-1
产品活性:LDH-IN-1是一种新的基于吡唑的人乳酸脱氢酶 (LDH) 抑制剂,对于 LDHA 和 LDHB的 IC50 值分别为32和27nM。
研究领域:Metabolic Enzyme/Protease
作用靶点:Lactate Dehydrogenase
In Vitro: LDH-IN-1 exhibits low nM inhibition of both LDHA and LDHB (IC50=32, 27 nM, respectively), submicromolar inhibition of lactate production, and inhibition of lactate in MiaPaCa2 pancreatic cancer and A673 sarcoma cells (IC50=0.517, 0.854μM, respectively). LDH-IN-1 inhibits the growth of MiaPaCa2 pancreatic cancer and A673 sarcoma cells with IC50s of 2.23 and 1.21 μM). Dose?response treatment of MiaPaCa-2 cells with LDH-IN-1 shows effects on cellular proliferation at concentrations as low as 250 nM and with nearly complete arrest of cell growth at 20 μM.
In Vivo: LDH-IN-1 shows clearance values that far exceed hepatic blood flow (HBF) in mouse species (90 mL/min/kg), with in vivo clearances of 227 mL/min/kg.
相关产品:Bioactive Compound Library Plus | Galloflavin | hDHODH-IN-2 | (R)-GNE-140 | Nifurtimox-d4 | LDHA-IN-3 | RS6212 | LDCA | hDHODH-IN-8 | hDHODH-IN-9 | LDHA-IN-5 | Nedosiran sodium | Nifurtimox | AXKO-0046 | PfDHODH-IN-1 | hDHODH-IN-1 | LDHA-IN-4 | NHI-2 | 3-Dehydrotrametenolic acid | hDHODH-IN-11 | Glomeratose A | FX-11 | D-Lactate dehydrogenase | Oxamic acid sodium | GSK2837808A | Isomalt
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