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CAS No. : 1262132-81-9
MCE 国际站:Enarodustat
产品活性:Enarodustat 是一种有效的,可口服的 hypoxia-inducible factor prolyl hydroxylase 抑制剂,EC50 of 0.22 μM。Enarodustat 有潜力用于肾性贫血症的研究。
研究领域:Metabolic Enzyme/Protease
作用靶点:HIF/HIF Prolyl-Hydroxylase
In Vitro: Enarodustat (JTZ-951) is a potent and orally active hypoxia-inducible factor prolyl hydroxylase inhibitor, with an EC50 of 0.22 μM. Enarodustat exhibits neither CYP (IC50 > 100 μM; CYP3A4/5, CYP2C9, CYP2D6, CYP1A2, CYP2A6, CYP2C19, CYP2C8, CYP2B6) nor hERG (IC50 > 100 μM) inhibition.
In Vivo: Enarodustat (1 and 3 mg/kg, p.o.) increases hemoglobin levels in a dose-dependent manner with daily oral dosing in rats.
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