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CAS No. : 1227367-59-0
MCE 国际站:Closthioamide
产品活性:Closthioamide 是细菌 DNA 促旋酶的一个有效抑制剂,其对 Ec,MRSA,VRE,Mv 的最小抑菌浓度分别是 9.00 μM, 0.58 μM, 0.58 μM 和 72.03 μM。
研究领域:Anti-infection
作用靶点:Bacterial
结构分类:抗生素 | 疾病研究 | 抗菌 | 酚类 | 多酚类 | 抗生素 | 其他类 | 结构分类
In Vitro: Closthioamide is a potent inhibitor of bacterial DNA gyrase, isolated from the strictly anaerobic banterium Clostridium cellulolyticum and belongs to a new class of natural products. In a standardized antimicrobial assay, it is found that closthioamide is highly active against a pathogenic, methicillin-resistant Staphylococcus aureus (MRSA) strain with a minimum inhibitory concentration (MIC) of 0.4 μg/mL-1 (0.58 μM). Closthioamide is even active against vancomycin-resistant Enterococcus faecalis (VRE) with the same low MIC value, and is thus significantly more potent against these bacteria than ciprofloxacin, the standard drugused against VRE, with remarkable strain selectivity. Furthermore, in a standardized cytotoxicity assay, closthioamide shows moderate antiproliferative and cytotoxic effects.
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