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CAS No. : 5928-25-6
MCE 国际站:Decursin
产品活性:Decursin ((+)-Decursin) 是一种有效的抗肿瘤剂。Decursin 还是一种细胞毒剂和有效的蛋白激酶 C (protein kinase C) 激活剂。Decursin 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 G1 期。Decursin 在 48 小时降低 CDK2、CDK4、CDK6、cyclin D1 蛋白的表达。Decursin 抑制细胞增殖和迁移。Decursin 具有抗肿瘤、抗炎和镇痛活性。
研究领域:Epigenetics | TGF-beta/Smad | Apoptosis | Immunology/Inflammation | GPCR/G Protein
作用靶点:PKC | Apoptosis | CXCR
结构分类:苯丙素类 | 香豆素 | 结构分类
来源:植物 | 伞形科 | 当归
In Vitro: Decursin (0, 25, 50, 100 μM; 24, 28, 72, 96 h) inhibits cell growth in a dose- and time- dependent manner in DU145 cells.
?Decursin (0, 25, 50, 100 μM; 24, 28, 72, 96 h) induces apoptosis and cell cycle arrest at G1 phase in DU145 cells, G1, S as well as G2-M arrests in PC-3 cells.
?Decursin (0, 25, 50, 100 μM; 24, 48 h) decreases the expression of? CDK2, CDK4, CDK6, cyclin D1 protein at 48 h in DU145 cells.
?Decursin (0, 5, 20, 100 μM; 7 days) inhibits the proliferation and differentiation ability of AC133+ cells.
?Decursin (0, 5, 20, 100 μM) inhibits SDF-1a-induced activation of Akt, ERK1/2, and?eNOS in a dose-dependent manner.
In Vivo: Decursin (4 mg/kg; s.c.; daily for 4 weeks) shows anti-tumor activity in mouse.
?Decursin (50 mg/kg; intrathecal injection; three times at 2-day intervals, for 6 days) shows analgesic ability in paclitaxel-induced peripheral neuropathy in mouse.
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