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Thapsigargin

CAS No. : 67526-95-8

MCE 国际站：Thapsigargin

产品活性：Thapsigargin，内质网应激诱导剂， 是一种微粒体 Ca²⁺-ATPase 抑制剂。Thapsigargin 能有效抑制不同细胞类型的病毒 (HCoV-229E、MERS-CoV、COVID-19) 复制。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling  |  Anti-infection  |  Apoptosis

作用靶点：Calcium Channel  |  SARS-CoV  |  Apoptosis

结构分类：萜类  |  二萜

来源：植物  |  伞形科  |  毒胡萝卜

In Vitro: Thapsigargin (0.001-?1 μM; for 2 and 4 days) arrests cell proliferations in MH7A human rheumatoid arthritis synovial cells in a time- and dose-dependent manner.
Thapsigargin (0.001-?1 μM; for 2 and 4 days) induces cell apoptosis in MH7A cells in a time- and dose-dependent manner.
Thapsigargin (0.001-?1 μM; for 2 and 4 days) impairs mTOR activity and leads to cyclin D1 expressions in MH7A cells.
Thapsigargin inhibits Ca²⁺ entry into human neutrophil granulocytes.
Thapsigargin inhibits the carbachol-evoked [Ca²⁺]i-transients with (IC₅₀=0.353 nM) or without (IC₅₀=0.448 nM) a KCl-prestimulation, but an additional small component, with a much lower sensitivity (IC₅₀=4814 nM), is observed in the absence of a KCl-prestimulation. In contrast, the KCl-evoked [Ca²⁺]i-transients displayed only one component with a very low sensitivity to Thapsigargin in both absence (IC₅₀=3343 nM) and presence (IC₅₀=6858 nM) of a carbachol-prestimulation.
Thapsigargin also phosphorylate p38 MAPK by Ca²⁺ influx through SOCE, leading to suppression of TNF-α-induced NF-κB phosphorylation.

In Vivo: Thapsigargin (Injection; 0.25 ug/g, 0.5 ug/g and 1 ug/g; 24 hours) significant increases of 2 to 5-fold in chemokine and pro-inflammatory expression. Thapsigargin is more sensitive to inducing a systemic immune response.

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