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Proanthocyanidins

CAS No. : 20347-71-1

MCE 国际站：Proanthocyanidins

产品活性：Proanthocyanidin (Procyanidin) 是一类在高等植物中广泛分布的多酚化合物，由亲电子黄烷酰基单元组成。Proanthocyanidin 可用作抗氧化剂和抗癌剂。Proanthocyanidin 还显示出抗炎，保护心脏，抗菌和抗真菌的特性，可用于研究慢性静脉功能不全、毛细血管脆弱、晒伤和视网膜病变。

研究领域：Anti-infection

作用靶点：Bacterial  |  Fungal

结构分类：黄酮类  |  双黄酮  |  酚类  |  多酚类  |  结构分类

来源：植物  |  其他科

In Vitro: Proanthocyanidin are present in plants as complex mixtures of polymers. Predominant food sources are red wine, tea, chocolate and fruits like grapes, apples, pears, and cranberries.
The most interesting antibacterial activity of Proanthocyanidin is related to their presence in cranberries (Vaccinium macrocarpon Ait.). A number of clinical trials have demonstrated the effectiveness of cranberry consumption in preventing urinary tract infections (UTIs). Although UTIs can be caused by many microorganisms, more than 85% are caused by Escherichia coli. The presence of P-fimbriae on E. coli, which are proteinaceous fibers on the bacterial cell wall, has been clearly established as a virulence factor, since they are responsible by producing adhesions for adherence to uroepithelial cells. Recently, it is demonstrated that cranberry Proanthocyanidin might inhibit P-fimbriated E. coli from adhering to uroepithelial cells. The antiadhesion activity of cranberry juice appears to be related to the presence of Proanthocyanidin with at least one A-type linkage.

In Vivo: The effects of cacao liquor Proanthocyanidin on 2- amino-1-methyl-6-phenylimidazo [4,5-b] pyridine-induced mutagenesis in vivo carcinogenesis in female Sprague-Dawley rats are investigated. In the Ames assay, Proanthocyanidin shows strong antimutagenic effects when assayed in the presence of S-9 mixture. They also inhibit significantly rat pancreatic carcinogenesis in the initiation stage, but not mammary carcinogenesis.

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