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CAS No. : 876310-60-0
MCE 国际站:RF9
产品活性:RF9 是一种有效且有选择性的神经肽 FF 受体 (Neuropeptide FF receptor) 拮抗剂 ,对于 hNPFF1R 和 hNPFF2R 的 Ki 值分别为 58 和 7 nM。
研究领域:GPCR/G Protein | Neuronal Signaling
作用靶点:Neuropeptide Y Receptor
In Vitro: RF9 (10 μM) pretrement completely blocks NPFF induced neurite outgrowth of Neuro 2A cells.
In Vivo: RF9 (0.1 mg/kg, s.c. ) with heroin coadministration prevents heroin-induced delayed hyperalgesia and tolerance.
RF9 (10 μg) infused alone does not result in a significant alteration of MAP or heart rate. Conversely, MAP and heart rate increases evoked by NPFF are significantly blocked when NPFF is applied in conjunction with RF9.
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