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CAS No. : 520-36-5
MCE 国际站:Apigenin
产品活性:Apigenin (4',5,7-Trihydroxyflavone) 是一种竞争性 CYP2C9 抑制剂,Ki 为 2 μM。
研究领域:Autophagy | Metabolic Enzyme/Protease
作用靶点:Autophagy | Cytochrome P450 | Endogenous Metabolite
结构分类:黄酮类 | 黄酮 | 酚类 | 多酚类 | 结构分类
来源:植物 | 伞形科 | 芹菜
In Vitro: Apigenin (4',5,7-Trihydroxyflavone) inhibits cytochrome P450 2C9 (CYP2C9) with a Ki of 2 μM in the CYP2C9 RECO system (a purified, reconstituted enzyme system containing recombinant human CYP2C9, P450 reductase, cytochrome b5, and liposomes). Apigenin inhibits cell proliferation. The growth inhibition rate (IR) of 20, 40, and 80 μM of Apigenin is 38%, 71%, and 99% respectively on the 7thd. after exposure to Apigenin for 24 or 48 h, the clone formation of SGC-7901 cells is suppressed in a dose- and time-dependent manner. The cloning efficiency in 80 μM is 9.8% and 5% after treatment with Apigenin for 24 and 48 h, while in the control group, it is 40.4% and 43.4%.
In Vivo: Apigenin (4',5,7-Trihydroxyflavone), a natural flavonoid, possesses a broad spectrum of biological properties, including antioxidative, anti-inflammatory, anticancer, and neuroprotective effects. Apigenin (125?mg/kg and 250 ?mg/kg) alleviates Adriamycin (ADR) (24?mg/kg)-induced myocardial injury. Apigenin inhibits serum aspartate amino transferase (AST) release. Apigenin reduces serum lactate dehydrogenase (LDH) release. Apigenin reduces serum creatine kinase (CK) contents.
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