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Oglufanide

CAS No. : 38101-59-6

MCE 国际站：Oglufanide

产品活性：Oglufanide (H-Glu-Trp-OH) 是一种从小牛胸腺中分离出来二肽免疫调节剂，可抑制血管内皮生长因子 (VEGF)。Oglufanide 可以刺激对丙型肝炎病毒 (HCV) 和细胞内细菌感染的免疫反应。Oglufanide 具有抗肿瘤和抗血管生成活性。

研究领域：Protein Tyrosine Kinase/RTK  |  Anti-infection  |  Metabolic Enzyme/Protease

作用靶点：VEGFR  |  HCV  |  Endogenous Metabolite

结构分类：酮、醛、酸  |  结构分类

In Vitro: Oglufanide (IM862) (1-1000 μg/mL) exhibits dose dependent inhibition of angiogenesis in the chorioallantoic membrane assay with complete inhibition of β-FGF and VEGF-induced angiogenesis.
?Oglufanide (L-glu-L-trp) (0-1000 μg/mL; 5 days) has no effect on the viability of either the tumor cell lines or HUVECs.

In Vivo: Oglufanide (L-glu-L-trp) (1-100 mg/kg/day; s.c.; 10 days) has antitumor activity in immunocompetent and immunodeficient mice.

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