MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Cynaroside

CAS No. : 5373-11-5

MCE 国际站：Cynaroside

产品活性：Cynaroside (Luteolin 7-glucoside) 是一种具有抗氧化能力的黄酮类化合物。Cynaroside 还是一种流感依赖的 RNA 聚合酶 抑制剂，IC₅₀ 为 32 nM。Cynaroside 也是一种应对 ₂O₂ 诱导的细胞凋亡的抑制剂，对氧化应激诱导的心血管疾病具有细胞保护作用。Cynaroside 还具有抗细菌、真菌和抗癌活性，以及抗氧化和抗炎活性。

研究领域：Anti-infection  |  Cell Cycle/DNA Damage  |  Apoptosis

作用靶点：Influenza Virus  |  DNA/RNA Synthesis  |  Apoptosis  |  Parasite  |  Bacterial  |  Fungal

结构分类：黄酮类  |  黄酮  |  酚类  |  多酚类

来源：植物  |  伞形科  |  峨参

In Vitro: Cynaroside promots macrophage phenotypic transition from pro-inflammatory M1 to anti-inflammatory M2, and mitigates sepsis-associated liver inflammatory damage.
Cynaroside reduces binding of PKM2 to hypoxia-inducible factor-1α (HIF-1α) by abolishing translocation of PKM2 to the nucleus and promoting PKM2 tetramer formation, as well as suppressing phosphorylation of PKM2 at Y105 in vivo and in vitro.
Cynaroside restores pyruvate kinase activity, inhibits glycolysis-related proteins including PFKFB3, HK2 and HIF-1α, and inhibits glycolysisrelated hyperacetylation of HMGB1 in septic liver.
Cynaroside protects H9c2 cells against H₂O₂-induced apoptosis by decreasing ROS generation and inhibiting caspase activation in both the mitochondrial and death receptor pathways.
Cynaroside maintains mitochondrial function by regulating Bcl-2 protein expression, as well as JNK and P53 expression.

In Vivo: Cynaroside (i.p.; 5mg/kg) reduces binding of PKM2 to hypoxia-inducible factor-1α (HIF-1α) by abolishing translocation of PKM2 to the nucleus and promoting PKM2 tetramer formation, as well as suppressing phosphorylation of PKM2 at Y105.

相关产品：Natural Product-like Compound Library  |  Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Apoptosis Compound Library  |  Cell Cycle/DNA Damage Compound Library  |  Anti-Cancer Compound Library  |  Antiviral Compound Library  |  Anti-Aging Compound Library  |  Antioxidant Compound Library  |  Glycoside Compound Library  |  Lipid Compound Library  |  Oxygen Sensing Compound Library  |  Antifungal Compound Library  |  Antibacterial Compound Library  |  Medicine Food Homology Compound Library  |  Phenols Library  |  Glycolysis Compound Library  |  Traditional Chinese Medicine Active Compound Library  |  Flavonoids Library  |  Antiparasitic Compound library  |  Anti-Parkinson's Disease Compound Library  |  Neurodegenerative Disease-related Compound Library  |  Food-Sourced Compound Library   |  Antiviral Traditional Chinese Medicine Active Compound Library  |  Human Metabolite Library  |  Heterocyclic Compound Library  |  SY-5609  |  Antifungal agent 26  |  Myricetin 3-O-α-L-arabinopyranoside  |  BRD4 Inhibitor-18  |  Ganoderic acid TR  |  8α-Tigloyloxyhirsutinolide 13-O-acetate  |  (1R,2S,7R)-Sitafloxacin-d₄ hydrochloride  |  Quinidine-d₃  |  Nebacumab  |  Angulatin G  |  Acridine Orange base  |  N-Desethyl amodiaquine-d₅  |  Gepotidacin  |  Amycolatopsin A  |  PC945  |  Palitantin  |  Antibiotic A-33853  |  Estradiol hemihydrate  |  AAPK-25  |  Sulbactam-d₂ sodium  |  Dutasteride-¹³C₆  |  IBU-DC Phosphoramidite  |  Oleic acid-¹³C  |  Antimicrobial agent-5  |  Proguanil-d₆  |  NBTIs-IN-4  |  Proanthocyanidins  |  Anticancer agent 120  |  Azlocillin sodium salt

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。