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Hemin

CAS No. : 16009-13-5

MCE 国际站：Hemin

产品活性：Hemin 是含铁的卟啉化合物。Hemin 是血红素加氧酶 (HO)-1 诱导剂。

研究领域：Autophagy  |  Apoptosis

作用靶点：Autophagy  |  Mitophagy  |  Ferroptosis

结构分类：其他类

In Vitro: Hemin and PGJ2, used as positive controls, strongly increase both expression and activity of HMOX after 4 and 12 h, respectively. Indeed, a significant effect is found of 30 μM Hemin on cell proliferation in all used cell lines after 48 h, which is dose-dependent. Hemin treatment decreases cell proliferation to 62±5 %, 51±3 %, and 38±8 % in PA-TU-8902, BxPC-3 and MiaPaCa-2 cancer cells, respectively, with p<0.0001 for all comparisons. Furthermore, enhancement of anti-proliferative effects of statins is observed by Hemin, documented as decreased cell proliferation after 48 h of co-treatment.

In Vivo: Following the i.p. administration of Hemin (100 μmol/kg), the HO-1 level in the renal cortex begins to increase gradually. The HO-1 level reaches its peak 24 h after Hemin preconditioning. HO-1 is expressed mainly in the renal tubules. The HO-2 level in the kidney does not change following Hemin preconditioning.

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