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CAS No. : 889665-86-5
MCE 国际站:Epiberberine chloride
产品活性:Epiberberine chloride 是从黄连中得到的生物碱,为有效的 AChE 和 BChE 抑制剂,和非竞争性的 BACE1 抑制剂,IC50 值分别为 1.07,6.03 和 8.55 μM。Epiberberine chloride 具有抗氧化作用,能够清除 ONOO- (IC50,16.83 μM),可用于阿尔滋海默症和糖尿病的研究。在 3T3-L1 细胞分化早期,Epiberberine 能够下调 Raf/MEK1/2/ERK1/2 和 AMPKα/Akt 信号通路。
研究领域:Neuronal Signaling | Metabolic Enzyme/Protease | Immunology/Inflammation | NF-κB
作用靶点:Cholinesterase (ChE) | Beta-secretase | Reactive Oxygen Species
结构分类:生物碱 | 异喹啉类生物碱
来源:植物 | 毛茛科 | 黄连
In Vitro: Epiberberine (0, 12.5, 25, or 50 μM) dose-dependently inhibits cellular triglyceride accumulation in 3T3-L1 adipocytes, with an IC50 of 52.8 μM.
Epiberberine (12.5-50 μM) suppresses the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways in the early stage of 3T3-L1 adipocyte differentiation.
Epiberberine (0.2, 1, 5 μg/mL) inhibits glucose uptake in HepG2 cells in a concentration-dependent manner.
In Vivo: Epiberberine (225 mg/kg, p.o. daily for 40 days) reduces body weight, food consumption, water intake, and urinary output of KK-Ay mice.
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