MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Leonurine hydrochloride

CAS No. : 24735-18-0

MCE 国际站：Leonurine hydrochloride

产品活性：Leonurine hydrochloride 是从 Leonurus artemisia 中分离到的生物碱，具有抗氧化、抗炎活性。

研究领域：Autophagy

作用靶点：Autophagy

结构分类：酚类  |  单酚类  |  生物碱  |  结构分类

来源：植物  |  菊科  |  宿根莴苣  |  植物  |  唇形科

In Vitro: Leonurine (0, 5, 10, 20, 40, 80 μM) causes diminution in lipid accumulation, cellular cholesterol content, including total cholesterol (TC), free cholesterol (FC) and cholesteryl ester (CE), and increase in apoA-I- or HDL-mediated cholesterol efflux after treatment for 24 h. Leonurine also significantly and dose-dependently increases the expressions of ABCA1 and ABCG1 at the mRNA and protein levels in human THP-1 macrophages, and such effect is involved in PPARγ. Leonurine hydrochloride (LH) shows protective effect on cell viability of HepG2 and HL-7702 cells incubated with palmitic acid (PA) of free fatty acid (FFA) for 24 h. Leonurine hydrochloride (125, 250, 500 μM) improves cellular lipid accumulation in HepG2 and HL-7702 cells via activating AMPK/SREBP1 pathway. Leonurine (5, 10, 20 μM) inhibits the expression of iNOS, COX-2, PGE2, NO, TNF-α, and IL-6 in IL-1β-induced human chondrocytes, suppresses ECM degradation in human OA chondrocytes, and blocks IL-1β-induced PI3K and Akt phosphorylation in a dose-dependent manner.

In Vivo: Leonurine (10 mg/kg/d, p.o.) significantly increases the expressions of PPARγ, LXRα, ABCA1 and ABCG1, and decreases both TG and TC levels in serum of mice. Leonurine hydrochloride (50, 100, 200 mg/kg) improves intracellular lipid accumulation via activating AMPK/SREBP1 pathway, enhances biochemical parameters, reduces hepatic lipoperoxide and increases antioxidant levels in mice. Leonurine (20 mg/kg, p.o.) ameliorates osteoarthritis development in mouse DMM model.

相关产品：Natural Product Library Plus  |  Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Natural Product Library  |  Anti-Cancer Compound Library  |  Autophagy Compound Library  |  Medicine Food Homology Compound Library  |  Phenols Library  |  Pyroptosis Compound Library  |  Traditional Chinese Medicine Active Compound Library  |  Alkaloids Library  |  Anti-Cancer Natural Product Library  |  Anti-inflammatory Traditional Chinese Medicine Active Compound Library  |  Plant-Sourced Natural Product Library  |  Human Metabolite Library  |  Pepstatin Ammonium  |  Meloxicam-d₃-1  |  Sorafenib-d₄  |  Carboplatin-d₄  |  Lapatinib ditosylate  |  AT9283  |  Erlotinib-d₆ hydrochloride  |  Ranolazine-d₈ dihydrochloride  |  6-Mercaptopurine-¹³C₂,¹⁵N  |  BIX-01294  |  Dinoprost-d₄  |  Curcumin  |  XRK3F2  |  Cysteamine-d₄ hydrochloride  |  Colistin sulfate  |  Salvianolic acid B  |  Aloperine  |  Topotecan hydrochloride hydrate  |  10074-G5  |  Tazarotene-d₈  |  Chenodeoxycholic acid-d₅  |  Carbamazepine-d₂  |  WYE-354  |  Retinoic acid  |  DBeQ  |  Flavopiridol  |  Trifluoperazine dihydrochloride  |  Salicylic acid-¹³C₆  |  Antitumor agent-97  |  Erlotinib Hydrochloride

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。