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CAS No. : 83-79-4
MCE 国际站:Rotenone
产品活性:Rotenone 是线粒体电子传递链复合物 I 抑制剂。 Rotenone 通过促进线粒体活性氧的产生来诱导细胞凋亡。
研究领域:Metabolic Enzyme/Protease | Autophagy | Apoptosis
作用靶点:Mitochondrial Metabolism | Autophagy | Apoptosis
结构分类:黄酮类 | 结构分类
In Vitro: Mitogen Activated Protein Kinase (MAPK), Toll-like receptor, Wnt, and Ras signaling pathways are intensively involved in the effect of rotenone on the ENS.
In Vivo: Rotenone can be used in animal modeling to construct Parkinson's syndrome models.
Rotenone causes a significant increase in the excitatory amino acid neurotransmitters; glutamate and aspartate together with a significant decrease in the inhibitory amino acids, GABA, glycine and taurine are observed in the cerebellum of rat model of PD. Rotenone (1.5, 2, or 2.5 mg/kg) causes a dose-dependent increase in α-synuclein in the substantia nigra. Furthermore, at 2 and 2.5 mg/kg, rotenone causes a significant decrease in the number of tyrosine hydroxylase-immunoreactive neurons in the substantia nigra, and dopamine in the striatum in rats.
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