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Protocatechuic acid

CAS No. : 99-50-3

MCE 国际站：Protocatechuic acid

产品活性：Protocatechuic acid 是一种天然多酚类物质，具有神经保护的作用。

研究领域：Metabolic Enzyme/Protease

作用靶点：Endogenous Metabolite

结构分类：酚类  |  多酚类  |  酮、醛、酸  |  结构分类

来源：植物  |  豆科  |  儿茶

In Vitro: Protocatechuic acid inhibits the aggregation of Aβ and αS and destabilizes their preformed fibrils. Protocatechuic acid prevents the death of PC12 cells triggered by Aβ- and αS-induced toxicity.

In Vivo: Protocatechuic acid is able to prevent stress induced immobility time in forced swim test without altering locomotor activity in mice. Further, Protocatechuic acid treatment attenuates the elevation of serum corticosterone, lipid peroxidation and restores enzymatic antioxidants in cerebral cortex and hippocampus in ARS mice. Rat administered cadmium and treated with prostigmine and doses of Protocatechuic acid (10 20 mg/kg) has significantly reduced BChE activity. Cadmium and either Prostigmine or Protocatechuic acid (10 20 mg/kg) treated rats shows significant reduction in MDA level.

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